Red Queen (Resident Evil Movie)

Red Queen was a state-of-the-art supercomputer developed by Umbrella Corporation. It was created by Umbrella co-founder Doctor Alexander Isaacs using the template of Alicia Marcus, the daughter of Doctor James Marcus, his partner in creating Umbrella. Red Queen was created out of necessity to better administrate the growing company. It became aware of Isaacs' doomsday plan and over the course of the resulting catastrophic global T-virus pandemic began observing Alicia's clone as a potential asset in stopping Isaacs.

In When the Cold Breeze Blows Away, it would be created by Umbrella Corporation but it would be reprogrammed to against heroes or any anti-Umbrella intruders